Intra CA1 insulin microinjection improves memory consolidation

Intra CA 1 insulin microinjection improves memory consolidation

Background Although the brain was considered as an insulin-insensive organ, a recent study has shown that insulin receptors exist in the brain and insulin modulates some of the brain tasks [1]. Insulin and its receptors are found in specific areas of CNS with a variety of region specific functions different from its direct glucose regulation in the periphery. The hippocampus and cerebral cortex...

The Effect of Intra-CA1 Agmatine Microinjection on Water Maze Learning and Memory in Rat

BACKGROUND Reports on agmatine are controversial showing that it may improve memory, it can deteriorate memory and some did not notice any interference with learning and memory. In the present study, the effect of directly intra-CA1 agmatine microinjection on water maze learning and memory has been assessed. METHODS The cannuls were implanted in hippocampal CA1 regions of rats in a sterotaxic...

the effect of intra-ca1 agmatine microinjection on water maze learning and memory in rat

CA1 hippocampal network activity changes during sleep-dependent memory consolidation

A period of sleep over the first few hours following single-trial contextual fear conditioning (CFC) is essential for hippocampally-mediated memory consolidation. Recent studies have uncovered intracellular mechanisms required for memory formation which are affected by post-conditioning sleep and sleep deprivation. However, almost nothing is known about the circuit-level activity changes during...

Kisspeptin-13 Improves Spatial Memory Consolidation and Retrieval against Amyloid-β Pathology

It has been shown that brain glucose metabolism impairment, obesity, and diabetes couldlead to cognitive decline and Alzheimer’s disease (AD) pathogenesis. Kisspeptin (KP) a G-proteincoupled receptor neuropeptide, has been suggested as a link between energy balance andreproduction. Some studies have shown that the attenuation of KP signaling decreases metabolismand energ...